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Effects of 780-nm Low-level Laser Therapy with a Pulsed Gallium Aluminum Arsenide Laser on the Healing of a Surgically Induced Open Skin Wound of Rat

Bayat M, Azari A, Golmohammadi MG.
Physical Therapy Research Group, Academic Center for Education, Culture, and Research, Iran Medical Science Branch University
Photomed Laser Surg. 2009 Oct 1

Abstract Objective

The aim of the present investigation is to evaluate the effects of a 780-nm low-level laser on open skin wound healing.

Background Data

Optimal parameters of low-level laser therapy (LLLT) for wound healing are discussed.


One full-thickness skin wound was surgically induced in the dorsum skin of 30 rats. The rats were divided into two groups. Rats in the experimental group were daily treated with a gallium aluminum arsenide (GaAlAs) laser (2 J/cm(2), lambda = 780 nm, pulse frequency of 2336 Hz). Rats in the sham-exposed group received LLLT with switched off equipment. After 4, 7, and 15 days, wounds were checked by histological and biomechanical methods. Data were analyzed by the Mann-Whitney U-test.


Fibroblasts, endothelium of blood vessels, blood vessel sections, and maximum stress were significantly increased, whereas macrophages were significantly decreased, compared with those of the sham-exposed group.


Pulsed LLLT with a 780-nm GaAlAs laser significantly accelerates the process of healing of surgically induced, full-thickness skin wounds in rat.